EPICUTIS® HydroBiomé Serum

Microbiome Support + Barrier Repair for Acne-Prone, Congested, and Inflamed Skin

If your skin feels constantly irritated, congested, reactive, or stuck in a cycle of breakouts and redness, the answer is not always more exfoliation or stronger acne treatments. Healthy skin starts with a balanced microbiome and a strong skin barrier.

EPICUTIS® HydroBiomé Serum is an advanced microbiome-supporting serum designed to improve overall skin health by helping calm visible irritation, support beneficial skin flora, and strengthen the skin barrier.

This lightweight, soothing formula is one of my favorite recommendations for clients with acne-prone, congested, and inflammation-driven skin who need support without overwhelming their complexion.

Why I Recommend It

Many clients with acne-prone skin focus only on treating breakouts, but long-term improvement often requires addressing the environment that allows inflammation and congestion to continue.

I love HydroBiomé Serum because it takes a different approach—it supports the skin’s natural ecosystem while helping calm visible irritation and reinforce the barrier.

This is especially beneficial for clients who experience:

• Frequent breakouts

• Congested pores

• Redness and sensitivity

• Inflammation

• Skin that feels reactive or easily disrupted

• Barrier damage from over-exfoliating or using too many active ingredients

Healthy skin is not just about removing what is unwanted—it is about supporting the systems that help your skin function properly.

The Technology Behind HydroBiomé Serum

EPICUTIS® HydroBiomé Serum combines two clinically studied active ingredients, TSC (tetrahydrocurcumin) and TPNa®, to support balanced, resilient skin.

TSC (Tetrahydrocurcumin)

A patented TLR2 modulator developed by Signum Biosciences, TSC works with the skin’s microbiome to help calm visible irritation and support a healthier-looking complexion.

This ingredient is especially beneficial for skin experiencing visible redness, inflammation, and breakout concerns because it helps support a more balanced inflammatory response.

TPNa® (Water-Soluble Vitamin E)

A next-generation form of Vitamin E selected for its antioxidant benefits and ability to support the skin barrier.

TPNa® helps strengthen skin resilience, defend against environmental stress, and support a healthier moisture barrier.

Together, these ingredients create a balanced approach to calming, strengthening, and supporting the skin.

Key Benefits

• Helps calm the appearance of redness and irritation

• Supports a healthier skin microbiome

• Helps reduce the look of congestion and breakout-prone skin

• Strengthens the skin barrier

• Provides antioxidant protection

• Supports balanced, resilient skin

• Helps improve overall skin health

Ideal For

• Acne-prone skin

• Congested skin

• Oily and combination skin

• Sensitive skin

• Redness-prone skin

• Inflamed skin

• Compromised skin barriers

• Skin recovering from overuse of harsh actives

How to Use

Apply morning and evening after cleansing.

HydroBiomé Serum can be used as a daily treatment serum and layers beautifully with other professional skincare products.

For acne-prone or congested skin, I recommend focusing on consistency and barrier support rather than constantly switching products or adding more aggressive treatments.

Katarina’s Honest Take

One of the biggest misconceptions I see with acne-prone skin is that the answer is always to exfoliate more or use stronger products.

In reality, many breakout-prone clients have skin that is overwhelmed, inflamed, or lacking proper barrier support.

HydroBiomé Serum is one of my favorite products for helping bring balance back to the skin. It supports the microbiome, calms visible inflammation, and helps create an environment where healthier skin can thrive.

Katarina’s Ritual

This is a product I personally recommend for clients who are experiencing redness, congestion, inflammation, or barrier disruption.

I especially love incorporating HydroBiomé Serum when a client’s skin needs a calming reset—whether they are recovering from an aggressive routine, experiencing increased sensitivity, or looking for support alongside acne treatments.

Pair It With

For a complete acne-supporting and barrier-focused routine, pair HydroBiomé Serum with:

• Gentle cleanser

• EPICUTIS® Lipid Serum for additional barrier support

• EPICUTIS® Hyvia Crème for hydration

• Mineral SPF

• Professional acne treatments when appropriate

Sensitive Skin Note

HydroBiomé Serum is designed with sensitive and reactive skin in mind, making it a beautiful option for clients who need effective support without unnecessary irritation.

If your skin feels inflamed, compromised, or overwhelmed by active ingredients, this is often a great place to start.

Healthy skin starts with balance—and supporting your microbiome is an important part of creating a stronger, calmer, more resilient complexion.